国产黑料

PhD. Department of Biochemistry & Molecular Biology, University of Leeds, Leeds, UK

BSc. Department of Biochemical Engineering, East China University of Science and Technology, Shanghai, China

Professor: 国产黑料 of Health Sciences, Pomona, CA, USA, 2023 - present

Associate Professor: 国产黑料 of Health Sciences, Pomona, CA, USA, 2018 - 2023

Assistant Professor: 国产黑料 of Health Sciences, Pomona, CA, USA, 2012 - 2018

Research Assistant Professor, Vanderbilt University, Nashville, TN, USA, 2010 - 2012

Research Fellow, Vanderbilt University, Nashville, TN, USA, 2004 - 2010

Stem cell biology, zebrafish-based drug screening and cancer biology.

My current research mainly focuses on 1) chemical approaches for stem cell/iPS cell cardiomyogenesis, 2) zebrafish-based drug screening, and 3) cancer biology.

By zebrafish-based screening, we have identified a number of small molecules which can modulate key signaling pathways such as BMP, Wnt/尾-catenin and Hedgehog pathways. As these key signaling pathways are involved in stem cell fate decisions and many types of human diseases including cancer, the small molecules that modulate these key pathways may control stem cell differentiation as well as serve leads for cancer drug development.

American Heart Association

American Associaiton for Cancer Resarech

国产黑料 of Health Sciences Research Committee, 2013 ~ Present

Research Advisory Committee, College of Veterinary Medicine,2012 ~ Present

Instructional Resource Committee,College of Veterinary Medicine,2012 ~ Present

Articles

2025

Kim, S.H. and Hao, J. (2025) 鈥淩ecent advances in diagnostic and therapeutic strategies for canine cognitive dysfunction鈥� 86, (5), American Journal of Veterinary Research, DOI:

2024

Kaur, G., Xie, C., Dong, C.Najera, J. Nguyen J.T. and *Hao, J(2024) "PDE4Dand miR-203 are promising biomarkers for canine atopic dermatitis", Mol Biol Rep 51, 651

Sun, J., Zhong, H., Kang, B., Lum, T., Liu,D., Liang, S.,*Hao, J. and *Guo, R. (2024) "Roles Of PD-L1 In Human Adipose-Derived Mesenchymal Stem Cells Under Inflammatory Microenvironment", Journal of Cellular Biochemistry, 1鈥�10.

2023

Xie, C., Wang, Z., Ba, Y., Aguilar, J., Kyan, A., Zhong, L., and *Hao, J. (2023) 鈥淏MP Signaling Inhibition Overcomes Chemoresistance of Prostate Cancer鈥�, American Journal of Cancer Research, (accepted)

Hu, X. and *Hao. J. (2023) "Mesenchymal Stem Cells and Their Derivatives for Skin Rejuvenation", International Journal of Biomedical Science 19(1), 26-30

Najera,Jand*Hao,J(2023)鈥淩ecentAdvanceinMesenchymalStemCellsTherapyforAtopic Dermatitis鈥�, Journal of Cellular Biochemistry, 124(2):181-187.

2022

Kaur, G., Ramirez, A., Xie, C., Clark, D., Dong, C., Maki, C., Ramos, T., Izadyar, F., Najera, SOL, Harb, J. and*Hao,J.(2022)鈥淎double-blindedplacebo-controlledevaluationofadipose-derivedmesenchymalstem cellsintreatmentofcanineatopicdermatitis鈥�.VeterinaryResearchCommunications,46(1):251-260.PMID: 34713306.

Meng, X., Wang, H., *Hao, J. (2022) 鈥淩ecent Progress in Drug Development for Fibrodysplasia Ossificans Progressiva鈥�. Molecular and Cellular Biochemistry, 477, 2327鈥�2334, PMID: 35536530.

2021

Xie, C., Lin, PJ. and *Hao, J. (2021) 鈥淓ggmanone Effectively Overcomes Prostate Cancer Cell Chemoresistance鈥�, Biomedicines, 9(5), 538. PMID: 34066000.

GaoB,ChenJ,HanB,ZhangX,HaoJ,GiulianoAE,CuiY,CuiX.(2021)"Identificationoftriptonideasa therapeutic agentfor triplenegativebreast cancer treatment". Sci Rep. Jan 28;11(1):2408. PMID:33510281.

2020

Xie, C.; Jiang, W.; Lacroix, J.J.; Luo,Y.; *Hao, J. (2020) Insight into Molecular Mechanism for Activin A- Induced Bone Morphogenetic Protein Signaling. International Journal of Molecular Sciences, 21, 6498. PMID: 32899497.

2019

Harb,J.,Lin,P.J.,and*Hao,J.(2019),鈥淩ecentDevelopmentofWntSignalingPathwayInhibitorsforCancer Therapeutics鈥�, Current Oncology Reports, 21(2):12. PMID: 30715618.

Li J. H. and *Hao J. (2019) 鈥淭reatment of Neurodegenerative Diseases with Bioactive Components ofTripterygiumwilfordii鈥�,TheAmericanJournalofChineseMedicine47(04)pp.769-785,PMID:31091976.

KouryJ.,RamirezA., XieC.,HarbJ,Dong C.,MakiC., RamosT.,IzadyarF.,ClarkD., Drechsler Y.,Kaur

G. and *Hao J. (2019) 鈥淧hosphodiesterase 4D, miR-203 and selected cytokines in the peripheral blood are associated with canine atopic dermatitis鈥�, PLOS ONE, 14(6):e0218670, PMID: 31226136.

2018

Xie,C.,Ramirez,A.,Wang,Z,Chow,Mand*Hao,J.(2018)鈥淎SimpleandSensitiveHPLC-MS/MSMethod for Quantification of Eggmanone in Rat Plasma and Its Application to Pharmacokinetics鈥�, Journal of Pharmaceutical and Biomedical Analysis, 153, p37-43. PMID: 29459234.

Li, H., Ha, H., Ding, X., Bae, C., Gazy, N., *Hao, J. and *Zhong, L (2018) 鈥淒MH4, a VEGFR2 Inhibitor, EffectivelySuppressesGrowthandInvasionofLungCancerCells鈥�,JournalofAppliedBiomedicine,16,46- 50.

2017

Botello-Smitha, WM, Alsamaraha, A, Chatterjeea, P, Xie, C, Lacroixc, JJ, *Hao. J and *Luo, Y (2017) 鈥淧olymodal Allosteric Regulation of Type 1 Serine/1 Threonine Kinase 2 Receptors via a Conserved Electrostatic Lock鈥�, PLOS Computational Biology 13(8): e1005711, PMID: 28827795.

*Hao,J,Unternaehrer,J,Cui,XJ,Cheng,NH,andOji,Y(2017)鈥淩egulationofStemnessinCarcinomaCells鈥�, Stem Cells International, Article ID 7681769, PMID:28819365.

Koury, J, Zhong, L,and *Hao, J (2017) 鈥淭argeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment鈥�, Stem Cells International, Article ID 2925869, PMID: 28356914.

Zhang X, Tian Y, Yang Y, *Hao J (2017) 鈥淒evelopment of anticancer agents targeting the Hedgehogsignaling鈥�. Cell Mol Life Sci.74, 2773鈥�2782, PMID:28314894.

Hao, J., Unternaehrer, J., Cui, X., Cheng, N., Oji, Y. (2017) 鈥淩egulation of Stemness in Carcinoma Cells鈥�, Stem Cell International (Special Journal Issue).

Taguchi T, Cho JY, Hao J, Nout-Lomas YS, Kang KS, Griffon DJ. (2017) 鈥淚nfluence of hypoxia on the stemness of umbilical cord matrix-derived mesenchymal stem cells cultured on chitosan films鈥�, J Biomed Mater Res B Biomater. PMID: 28188976.

2016

WangZ,RavulaR,ShiL,SongY,YeungS,LiuM,LauB,Hao,J,WangJ,LamCW,ChowMS,HuangY. (2016) 鈥淥vercoming chemoresistance in prostate cancer with Chinese medicine Tripterygium wilfordii via multiple mechanisms鈥�, Oncotarget. 7, 61246-61261. PMID: 27487134

Pang, J, Zuo, Y, Chen, Y, Song, L, Zhu, Q, Yu, J, Shan, C., Cai, Z., Hao, J, Kaplan, FS, Shore, EM, Zhang, K(2016) 鈥淎CVR1-Fc Suppresses BMP Signaling andChondro-osseous Differentiation in an in vitro Model of Fibrodysplasia Ossificans Progressiva鈥�, Bone. 92, 29-36. PMID: 27492611

Luo,Y,Alsamarah,A,Zhang,Kand*Hao,J(2016)鈥淒evelopmentofNewTherapeuticAgentsfor Fibrodysplasia Ossificans Progressiva鈥�, Current Molecular Medicine, 16, 1-8, PMID: 26695699.

Chinison, J, Aguilar JS, Avalos A, Huang, Y, Wang, Z, Cameron, DJ, and *Hao, J (2016) "Triptonide Effectively Inhibits Wnt/尾-Catenin Signaling via C-terminal Transactivation Domain of 尾-catenin". Scientific Reports. 6, 32779. PMID: 27596363.

2015

Aguilar,JS,Begum,AN,Alvarez,J,Zhang,X,Hong,Yand *Hao,J(2015)鈥淒irectedcardiomyogenesis of human pluripotent stem cells by modulating Wnt/尾-catenin and BMP signalingwith small molecules鈥�, Biochemical Journal, 469 (2) 235-241. PMID: 26171831.

Alsamarah, A., LaCuran,AE., Oelschlaeger, P., *Hao, J and *Luo, Y. (2015) 鈥淯ncovering Molecular Bases Underlying Bone Morphogenetic Protein Receptor Inhibitor Selectivity鈥�, PLoS One, 10(7):e0132221. PMID: 26133550.

Zhang, X., *Hao, J (2015) 鈥淒evelopment of Anticancer Agents Targeting the Wnt/尾-catenin Signaling鈥�, American Journal of Cancer Research, 5(8):2344-2360, PMID: 26396911.

Begum, AN, Guoynes, G, Cho, J, Hao, J, Lutfy, K and Hong, Y (2015) 鈥淩apid generation of sub-type, region-specificneuronsandneuralnetworksfromhumanpluripotentstemcell-derivedneurospheres鈥�,Stem Cell Research, 15, 731-741. PMID: 26613348

Han, B.C, Qu, Y, Jin, Y.L, Yu, Y, Deng, N, Wawrowsky, K, Zhang, X, Li, N, Bose, S, Liu, Z, Wang, Q, Sakkiah, S, Abrol, R, Kang, S, Zhou, X, Johnson, J, Gao, B, Hao, J, Buttyan, R, Ray, P.S, Hung, M.C, Giuliano, A, Cui, X (2015) 鈥淔OXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer鈥�, Cell Reports, 13, 1-13. PMID: 26565916

Williams CH, Hempel JE, Hao J, Frist AY, Williams MM, Fleming JT, Sulikowski GA, Cooper MK, Chiang C, Hong CC. (2015) 鈥淎n In Vivo Chemical Genetic Screen Identifies Phosphodiesterase 4 as a PharmacologicalTargetforHedgehogSignalingInhibition鈥�,CellReports,11,p43鈥�50.PMID:25818300

2014

*HaoJ,GalindoCL,TranTL,SawyerDB.(2014)"Neuregulin-1尾inducesembryonicstemcellcardiomyogenesis via ErbB3/ErbB2 receptors", Biochemical Journal. 458, 335-341. PMID: 24364879.

*Hao, J, Lee, R, Chang, A, Fan, J, Labib C, Parsa, C, Orlando, R, Andresen, B. and *Huang, Y (2014) 鈥淒MH1,ASmallMoleculeInhibitorofBMPTypeIReceptors,SuppressesGrowthandInvasionofLung Cancer鈥�, PLoS One, 9, e90748. PMID: 24603907.

Hong,CC,Ao,AandHao,J(2014)"ChemicalBiologyinRegenerativeMedicine:BridgingStemCellsand Future Therapies鈥�, John Wiley & Sons Inc. ISBN978-1-118-34959-5 (Book)

Sheng,CC,Hao,JandHong,CC.(2014)鈥淐hemicallyInducedPluripotentStemCells(CiPSCs):APotential ChemicalBiologicalBreakthroughinReprogramming?鈥� JohnWiley&SonsInc.ISBN:978-1-118-34959-5, 95-101.

2013

Sheng, CC, Zhou, L and *Hao, J (2013) 鈥淐urrent Stem Cell Delivery Methods for Myocardial Repair鈥�, BioMed Research International, Article ID 547902, PMID: 23509740.

Hao, J, Ao, A, Zhou,L,Murphy, CK, Frist, AY, Keel, JJ, Throne, CA,Kim, K, Lee,E,Hong, CC.(2013) "Selective Small Molecule Targeting beta-Catenin Function Discovered by In Vivo Chemical Genetic Screen",Cell Reports 4, 898-904, PMID: 24012757.

Han, G.F, Wang, H.T, and *Hao, J (2013) "Molecular Mechanisms of Embryonic Stem Cell Pluripotency", Pluripotent Stem Cells", INTECH press, ISBN 978-953-51-1192-4, 283-299

2012

AoA,HaoJ,HopkinsCRandHongCC.(2012)鈥淒MH1,aNovelBMPSmallMoleculeInhibitor,Increases Cardiomyocyte Progenitors and Promotes Cardiac Differentiation in Mouse Embryonic Stem Cells鈥�, PLoS One, 7, e41627. PMID: 22848549

2011

*Hao, J, Sawyer, DB., Hatzopoulos, AK and Hong, CC (2011) 鈥淩ecent progress on chemical biology of pluripotent stem cell: self-renewal, reprogramming and cardiomyogenesis鈥�, Recent Patents on Regenerative Medicine, 1, 263-274. PMID: 22787575

#Wang,H.,#*Hao,J,*Hong,CC.(2011)鈥淐ardiacinductionofembryonicstemcellsbyasmallmolecule inhibitor of Wnt/尾-catenin signaling鈥�, ACS Chemical Biology, 6, 192鈥�197 (# first author). PMID: 21077691

Ao,A,Williams,CH,*Hao,J,*Hong,CC.(2011)鈥淢odifiedmouseembryonicstemcell-basedassayfor quantifying cardiogenic induction efficiency鈥�, J Vis Exp., 50, 2656. PMID: 21540823

Ao,A.,Hao,J,Hong,CC.(2011)鈥淩egenerativechemicalbiology:currentchallengesandfuturepotentials鈥�, Chemistry & Biology, 18, 413-424. PMID: 21513877

Wiley,DM.,Kim,JD,Hao,J,Hong,CC.,Bautch,VL,Jin,SK(2011)鈥淒istinctsignalingpathwaysregulate sprouting angiogenesis from the dorsal aorta and axial vein鈥�, Nature Cell Biology, 13, 686鈥�692. PMID: 21572418

Hao,J,窜丑辞耻,尝,贬辞苍驳,颁颁(2011)鈥淐丑别尘颈肠补濒产颈辞濒辞驳测辞蹿辫濒耻谤颈辫辞迟别苍迟蝉迟别尘肠别濒濒蝉:贵辞肠耻蝉辞苍肠补谤诲颈辞尘测辞驳别苍别蝉颈蝉鈥�, Embryonic Stem Cells - Recent Advances in Pluripotent Stem Cell-Based Regenerative Medicine, INTECH, ISBN: 978-953-307-1985, 51-64

2010 and Before

Hao,J.,Daleo, MA and Hong, CC. (2010) 鈥淐rosstalk between mitogen activated protein kinase and phosphoinositide-3 kinase signalling pathways in development and disease鈥�, Systems Biology for Signaling Networks, , Springer, New York, ISBN:978-144-195-7962, 505-529

Hao, J, Williams, C H., Webb, M E., Hong, CC. (2010) 鈥淟arge scale zebrafish-based in vivo small molecule screen鈥�, J. Vis. Exp., 46, 2243

Hao, J, Ho, JN, Lewis, JA, Karim, K, Daniels, RN, Gentry, PR, Hopkins, CR, Lindsley, CW and Hong CC. (2010) 鈥淚n vivo structure activity relationship study of dorsomorphin analogs identifies selective VEGF and BMP inhibitors鈥�,ACS Chemical Biology, 5, 245鈥�253

Hao, J, Daleo, MA and Hong, CC (2010) 鈥淐rosstalk between mitogen activated protein kinase and phosphoinositide-3 kinase signalling pathways in development and disease鈥�, Systems Biology for Signaling Networks, Springer, New York, ISBN: 978-144-195-7962, 505-529

Hao,J., Daleo MA, Murphy, CK, Yu, PB, Ho, JN, Hu J, Peterson, RT., Hatzopoulos, AK., Hong, CC. (2008) 鈥淒orsomorphin, a Selective Small Molecule Inhibitor of BMP Signaling, Promotes Cardiomyogenesis in Embryonic Stem Cells鈥�, PLoS ONE, 3, e2904

Hao, J., Vann, WF., Hinderlich, S. and Sundaramoorthy, M. (2006)鈥淓limination of 2-keto-3-dexoy-D-glycero-D-galacto-nonulosonic acid 9-phosphate synthase activity from human N-acetylneuraminic acid 9-phosphate synthase by a single mutation鈥�, Biochem. J. 397, 195-201

Hao, J.,Balagurumoorthy, P., Sarilla, S. and Sundaramoorthy, M. (2005)鈥淐loning, expression and characterization of sialic acid synthases鈥�, Biochem. Biophys. Res. Comm. 338,1507-1514

Hao, J..and Berry, A. (2004) 鈥淎 thermostable variant of fructose bisphosphate aldolase constructed by directed evolution also shows increased stability in organic solvents鈥�, Protein Eng, Des and Sel. 17, 689-697

1. Hao, J, Daleo MA, Murphy,CK, Yu, PB,Ho, JN,Hu J, Peterson, RT, Hatzopoulos, AK, Hong, CC. (2008) 鈥淒orsomorphin, a Selective Small Molecule Inhibitor of BMP Signaling, Promotes Cardiomyogenesis in Embryonic Stem Cells鈥�, PLoS ONE, 3, e2904. PMID: 18682835

2. Hao, J, Vann, WF, Hinderlich, S. and Sundaramoorthy, M. (2006) 鈥淓limination of 2-keto-3-dexoy-D- glycero-D-galacto-nonulosonic acid 9-phosphate synthase activity from human N-acetylneuraminic acid 9-phosphate synthase by a single mutation鈥�, Biochem. J. 397, 195-201. PMID: 16503877

3. Hao, J, Balagurumoorthy, P., Sarilla, S. and Sundaramoorthy, M. (2005) 鈥淐loning, expression and characterization of sialic acid synthases鈥�, Biochem. Biophys. Res. Comm. 338, 1507-1514. PMID: 16274664

4. Hao, J and Berry, A. (2004) 鈥淎 thermostable variant of fructose bisphosphate aldolase constructed by directed evolution also shows increased stability in organic solvents鈥�, Protein Eng, Des and Sel. 17, 689- 697. PMID: 15531627

Book,BookChapters,andJournal Issue

1. Hao, J., Unternaehrer, J., Cui, X., Cheng, N., Oji, Y. (2017) 鈥淩egulation of Stemness in Carcinoma Cells鈥�, Stem Cell International (Special Journal Issue).

2. Hong,CC,Ao,AandHao,J(2014)"ChemicalBiologyinRegenerativeMedicine:BridgingStemCellsand Future Therapies鈥�, John Wiley & Sons Inc. ISBN978-1-118-34959-5 (Book)

3. Sheng,CC,Hao,JandHong,CC.(2014)鈥淐hemicallyInducedPluripotentStemCells(CiPSCs):APotential ChemicalBiologicalBreakthroughinReprogramming?鈥� JohnWiley&SonsInc.ISBN:978-1-118-34959-5, 95-101.

4. Han, G.F, Wang, H.T, and *Hao, J (2013) "Molecular Mechanisms of Embryonic Stem Cell Pluripotency", Pluripotent Stem Cells", INTECH press, ISBN 978-953-51-1192-4, 283-299

5. Hao,J,窜丑辞耻,尝,贬辞苍驳,颁颁(2011)鈥淐丑别尘颈肠补濒产颈辞濒辞驳测辞蹿辫濒耻谤颈辫辞迟别苍迟蝉迟别尘肠别濒濒蝉:贵辞肠耻蝉辞苍肠补谤诲颈辞尘测辞驳别苍别蝉颈蝉鈥�, Embryonic Stem Cells - Recent Advances in Pluripotent Stem Cell-Based Regenerative Medicine, INTECH, ISBN: 978-953-307-1985, 51-64

6. Hao, J, Daleo, MA and Hong, CC (2010) 鈥淐rosstalk between mitogen activated protein kinase and phosphoinositide-3 kinase signalling pathways in development and disease鈥�, Systems Biology for Signaling Networks, Springer, New York, ISBN: 978-144-195-7962, 505-529

Patents

Charles C. Hong, Corey R. Hopkins, Antonis K. Hatzopoulos, Craig W. Lindsley, Jijun Hao. 鈥淐ompounds and methods useful for directing stem cell differentiation鈥�, Patent number: US9040694B1

Charles C. Hong, Charles H. Williams, Jonathan Hempel, T K Feaster, Don H. Rubin, Gary Sulikowski, Jijun Hao, Audrey Frist. 鈥淐ompounds and methods for inhibition of hedgehog signaling and phosphodiesterase鈥�. Patent number: 10329304

Charles C. Hong, Charles H. Williams, Jonathan Hempel, T K Feaster, Don H. Rubin, Gary Sulikowski, Jijun Hao, Audrey Frist. 鈥淐ompounds and Methods for Inhibition of Hedgehog Signaling and Phosphodiesterase鈥�. Patent number: US2017190717A1

Selected Achievements in Small Molecule Development

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